Effect of amitriptyline on learning and memory consolidation in the male Wistar rats with an experimental model of pentylenetetrazole-induced seizure

Amitriptyline (AMT) was developed for the treatment of chronic and neuropathic pain. There is also evidence it may be useful in neurodegenerative disorders. In this regard, effect on experimental model seizures memory impairment caused by rats investigated present study. Seizures Wistar (200-250 g) were induced pentylenetetrazole (PTZ, 60 mg/kg, intraperitoneally (i.p.)). The anticonvulsant AMT (10 20 i.p.) evaluated seizure model. assessed using passive avoidance (PA) learning test. After behavioral tests, animals underwent deep anesthesia put down painlessly. Animal serum isolated oxidant/antioxidant assays (malondialdehyde (MDA), glutathione peroxidase (GPx)). Intraperitoneal injection decreased mean number myoclonic jerks generalized tonic-clonic (GTCS) duration increased latency jerk GTCS compared to PTZ group. Moreover, PA test, a significant increase retention (RL) total time spent light compartment (TLC) Biochemical tests showed that able significantly GPx levels reduce MDA Overall, study suggests potential neuroprotective effects drug via mechanism inhibition oxidative stress pathway.